Benzylurea → 7-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

HRID 1481159Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1481159
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11](Br)[CH:10]=2)=[O:5])[CH3:2].[CH2:18]([NH:25][C:26]([NH2:28])=[O:27])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[C:14]([C:15]=1[OH:16])=[CH:13][CH:12]=[C:11]([NH:28][C:26]([NH:25][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=[O:27])[CH:10]=2)=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 10853BenzylureaHCID 89813095Ethyl 7-bromo-4-hydroxyisoquinoline-3-carboxylate

Produkt 1

HCID 898129357-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester

Versuchsvorschrift

7-(3-Benzyl-ureido)-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester was prepared from 7-bromo-4-hydroxy-isoquinoline-3-carboxylic acid ethyl ester under conditions analogous to Example 116(a) using benzyl urea. The crude product was used in the following steps without purification.

Aufarbeitung

  1. customThe crude product was used in the following steps without purification

Quellen und Nachweise

ORD-Eintrag
ord-903b8f274c344b76a30020c6768cd8a8
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409892B2

Notizen zur Reaktion

Wird geladen…