3-Methoxytyramine → 4-{2-[4-(3-Butoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-2-methoxy-phenol

HRID 14813

Reaktionsgleichung

Reaktionsgleichung von HRID 14813
[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][N:15]=[C:14](Cl)[N:13]=2)[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4].[NH2:19][CH2:20][CH2:21][C:22]1[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([O:29][CH3:30])[CH:23]=1>>[CH2:1]([O:5][C:6]1[CH:7]=[C:8]([C:12]2[CH:17]=[CH:16][N:15]=[C:14]([NH:19][CH2:20][CH2:21][C:22]3[CH:27]=[CH:26][C:25]([OH:28])=[C:24]([O:29][CH3:30])[CH:23]=3)[N:13]=2)[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4]

Komponenten

3

Edukt 2

HCID 16693-MethoxytyramineHCID 866032734-(3-Butoxy-phenyl)-2-chloro-pyrimidine

Produkt 1

HCID 586035384-{2-[4-(3-Butoxy-phenyl)-pyrimidin-2-ylamino]-ethyl}-2-methoxy-phenol

Versuchsvorschrift

Intermediate 46 was coupled with 4-(2-Amino-ethyl)-2-methoxy-phenol following procedure F. LC-MS showed the product had the expected M+H+ of 394. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) δ 8.3 (m, 1H) 7.6 (m, 2H) 7.35 (m, 1H) 7.0 (m, 2H) 6.85 (m, 1H) 672 (m, 2H) 5.51 (br s, 1H) 4.0 (t, 2H) 3.75 (s, 3H) 3.7 (m, 2H) 2.89 (t, 2H) 1.78 (d, 2H) 1.5 (d, 2H) (t, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-d663147eca2b40e49e3f745f2596ec2e
Quelldatensatz
uspto-grants-2010_06
Patentnummer
US07732444B2

Verknüpfte Notizen

Wird geladen…