Dimethyl methoxymethylenemalonate → HCID 71284791, Verbindung

HRID 1481681Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1481681
CC([N:5]=[C:6]([C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]([CH3:20])[CH2:15][CH2:14][CH2:13]2)[CH2:7][CH2:8][CH3:9])(C)C.C[O:22][CH:23]=[C:24]([C:29]([O:31][CH3:32])=[O:30])[C:25](OC)=O>COCCOCCOC>[CH2:8]([C:7]1[CH:25]=[C:24]([C:29]([O:31][CH3:32])=[O:30])[C:23](=[O:22])[NH:5][C:6]=1[C:10]1[CH:11]=[C:12]2[C:17](=[CH:18][CH:19]=1)[N:16]([CH3:20])[CH2:15][CH2:14][CH2:13]2)[CH3:9]

Komponenten

4

Edukt 2

HCID 90770Dimethyl methoxymethylenemalonateHCID 89422940HCID 89422940, Verbindung

Produkt 1

HCID 71284791HCID 71284791, VerbindungAusbeute 17,1 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8150DiglymeLösungsmittel

Reaktionsbedingungen

Temperatur
160 °C

Versuchsvorschrift

To a suspension of 2-methyl-N-(1-(1-methyl-1,2,3,4-tetrahydroquinolin-6-yl)butylidene)propan-2-amine (1.96 g, ca. 7.2 mmol) in diglyme (7 mL) was added dimethyl 2-(methoxymethylene)malonate (2.12 g, 12.2 mmol, 1.7 eq). The reaction was stirred at 160° C. for 3 h then was cooled to room temperature. The precipitate was collected by filtration then washed with Et2O to afford the title compound (402 mg, ca. 1.23 mmol) which was carried over to next step without further purification.

Aufarbeitung

  1. temperaturethen was cooled to room temperature
  2. filtrationThe precipitate was collected by filtration
  3. washthen washed with Et2O

Quellen und Nachweise

ORD-Eintrag
ord-25bf2ced89464f15b55c79841e0b3abd
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09409905B2

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