[O:1]([C:3]1[CH:4]=[CH:5][C:6]2[N:10]=[N:9][NH:8][C:7]=2[CH:11]=1)[CH3:2].[OH-].[Na+].[Cl:14][CH2:15][CH2:16][CH2:17]Br>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC>[Cl:14][CH2:15][CH2:16][CH2:17][N:8]1[C:7]2[CH:11]=[C:3]([O:1][CH3:2])[CH:4]=[CH:5][C:6]=2[N:10]=[N:9]16-methoxyl-1H-benzotriazole (14.9 g, 0.10 mol) is dissolved into 100 ml of 30% wt. sodium hydroxide, 3-chlorobromopropane (31.4 g, 0.10 mol), tetrabutyl ammonium bromide (0.8 g) are added, and mixed for 5 min. The reaction solution is gradually heated to 60° C., stirred for reaction for 2 hours. Post treatment was performed based on common method two for synthesis. The solution was separated and purified by HPLC to produce 7.7 g of 1-(3-chloropropyl)-6-methoxyl-1H-benzotriazole, with a yield of 34.1%.
Wird geladen…
