Sodium Bicarbonate → 4-((3-(3-(Trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanol

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Sodium Bicarbonate	HCID 516892	—
Edukt	6-Chloro-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine	HCID 59379861	—
Edukt	HCID 178479277	HCID 178479277	—
Lösungsmittel	N-methyl-2-pyrrolidone	HCID 13387	—
Produkt	4-((3-(3-(Trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanol	HCID 24996072	32%

Reaktionsbedingungen

Temperatur	180 °C

Reaktionsschritte

To a solution of 6-chloro-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazine (200 mg, 0.64 mmol) and cis-4-aminocyclohexanol hydrogenchloride (367 mg, 3.19 mmol) in NMP (2.0 mL) was added NaHCO3 (268 mg, 3.19 mmol), the mixture was stirred at 180° C. for 45 mins under microwave irridation. The mixture was purified by flash chromatograph to give 4-((3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-yl)amino)cyclohexanol (80 mg, 32%) as a pale yellow solid.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US09416132B2
Quelldatensatz	uspto-grants-2016_08
ORD ID	ord-0e975d04ea0544b5b8ad68996bdc752f
Quellennotiz	uspto-grants-2016_08