Trifluoroacetic acid → HCID 86718556, Verbindung
Reaktionsgleichung
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[C:16]3[N:17]([C:37]([CH3:40])=[N:38][N:39]=3)[N:18]=[C:19]([C:21]3[N:22]([CH2:30][C:31]4[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=4)[C:23]4[C:28]([CH:29]=3)=[CH:27][CH:26]=[CH:25][CH:24]=4)[CH:20]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:30]([N:22]1[C:23]2[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:29]=[C:21]1[C:19]1[CH:20]=[C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[C:16]2[N:17]([C:37]([CH3:40])=[N:38][N:39]=2)[N:18]=1)[C:31]1[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
4-[6-(1-Benzyl-1H-indol-2-yl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (13 mg; 0.02 mmol) was dissolved in 1 ml DCM and treated with 300 μl TFA. It was stirred for 1 hour. The solvent was evaporated and the residue taken up in DCM and extracted with aqueous NaHCO3. The organic layer was dried and evaporated to dryness.