Hydrochloric Acid → 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

HRID 1485510Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1485510
[NH2:1][C:2]1[C:3]2[S:25][CH:24]=[C:23]([C:26]3[CH:27]=[C:28]([CH:33]=[CH:34][CH:35]=3)[C:29]([NH:31][CH3:32])=[O:30])[C:4]=2[N:5]=[C:6]([NH:8][C:9]2[CH:10]=[N:11][C:12]([N:15]3[CH2:20][CH2:19][N:18]([CH2:21][CH3:22])[CH2:17][CH2:16]3)=[CH:13][CH:14]=2)[N:7]=1.[ClH:36]>O1CCCC1.O1CCOCC1>[ClH:36].[NH2:1][C:2]1[C:3]2[S:25][CH:24]=[C:23]([C:26]3[CH:27]=[C:28]([CH:33]=[CH:34][CH:35]=3)[C:29]([NH:31][CH3:32])=[O:30])[C:4]=2[N:5]=[C:6]([NH:8][C:9]2[CH:10]=[N:11][C:12]([N:15]3[CH2:16][CH2:17][N:18]([CH2:21][CH3:22])[CH2:19][CH2:20]3)=[CH:13][CH:14]=2)[N:7]=1

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 532374933-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide

Produkt 1

HCID 532395413-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 8028TetrahydrofuranLösungsmittelHCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

3-(4-Amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide (300 mg, 0.615 mmol) was dissolved in tetrahydrofuran (5 mL) and then 4 M hydrogen chloride (169 μL) dissolved in dioxane was added at room temperature. 5 hours later, thus prepared precipitate was filtered and dried at room temperature. The target compound 3-(4-amino-2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)-N-methylbenzamide hydrochloride (295 mg) was yielded.

Aufarbeitung

  1. additionwas added at room temperature
  2. filtration5 hours later, thus prepared precipitate was filtered
  3. customdried at room temperature

Quellen und Nachweise

ORD-Eintrag
ord-59bf86c5950e4ee1920c057253892c1e
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09422307B2

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