Hydrochloric Acid → HCID 88415079, Verbindung

HRID 1486261Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486261
[NH2:1][C:2]([CH3:16])([C:12]([F:15])([F:14])[F:13])[CH2:3][NH:4]C(=O)OC(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[ClH:17].[F:13][C:12]([F:15])([F:14])[C:2]([CH3:16])([NH2:1])[CH2:3][NH2:4]

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 90136051rac-tert-Butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate

Produkt 1

HCID 88415079HCID 88415079, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel2×

Versuchsvorschrift

15 g (61.9 mmol) of rac-tert-butyl (2-amino-3,3,3-trifluoro-2-methylpropyl)carbamate from Example 51A in dioxane (188 ml) were admixed with 188 ml of 4 M hydrogen chloride in dioxane. The reaction mixture was stirred at RT for 16 h, then concentrated and stored under argon. This gave 14.4 g (108% of theory) of the target compound, which was not purified any further.

Aufarbeitung

  1. concentrationconcentrated
  2. customThis gave 14.4 g (108% of theory) of the target compound, which was not purified any further

Quellen und Nachweise

ORD-Eintrag
ord-97e5fa5daa2b487693a6cc4234586815
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09422285B2

Notizen zur Reaktion

Wird geladen…