4-Chloro-3-nitrobenzaldehyde → HCID 86706528, Verbindung

HRID 1486698Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486698
ClC1C=CC(C=O)=CC=1[N+]([O-])=O.C1(NC(C2CCNCC2)=O)CCCCC1.[CH:28]1([NH:34][C:35]([CH:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]3[CH:49]=[CH:48][C:47]([Cl:50])=[C:46]([N+:51]([O-])=O)[CH:45]=3)[CH2:39][CH2:38]2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1>>[CH:28]1([NH:34][C:35]([CH:37]2[CH2:42][CH2:41][N:40]([CH2:43][C:44]3[CH:49]=[CH:48][C:47]([Cl:50])=[C:46]([NH2:51])[CH:45]=3)[CH2:39][CH2:38]2)=[O:36])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]1

Komponenten

4

Edukt 3

HCID 855054-Chloro-3-nitrobenzaldehydeHCID 12410238n-Cyclohexylpiperidine-4-carboxamideHCID 86706529HCID 86706529, Verbindung

Produkt 1

HCID 86706528HCID 86706528, Verbindung

Versuchsvorschrift

The title compound is prepared according to the reactions described above starting from 4-chloro-3-nitro-benzaldehyde and piperidine-4-carboxylic acid cyclohexylamide yielding after reductive amination 1-(4-Chloro-3-nitro-benzyl)-piperidine-4-carboxylic acid cyclohexylamide LC-MS A: tR=0.67 min; [M+H]+=380.03 and reduction with stannous chloride the title compound LC-MS A: tR=0.63 min; [M+H]+=350.21.

Aufarbeitung

  1. customThe title compound is prepared

Quellen und Nachweise

ORD-Eintrag
ord-43632e1327164b87bd229c6014243e9d
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428456B2

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