Cyclohexylamine → 4-Fluoro-piperidine-4-carboxylic acid cyclohexylamide

HRID 1486731Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486731
C(OC([N:8]1[CH2:13][CH2:12][C:11]([F:17])([C:14]([OH:16])=O)[CH2:10][CH2:9]1)=O)(C)(C)C.[CH:18]1([NH2:24])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1.C(OC(N1CCC(C(=O)NC2CCCCC2)CC1)=O)(C)(C)C>>[CH:18]1([NH:24][C:14]([C:11]2([F:17])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)=[O:16])[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Komponenten

4

Edukt 3

HCID 7965CyclohexylamineHCID 4273089N-Cyclohexyl 1-boc-piperidine-4-carboxamideHCID 210503971-(tert-Butoxycarbonyl)-4-fluoropiperidine-4-carboxylic Acid

Produkt 1

HCID 847260354-Fluoro-piperidine-4-carboxylic acid cyclohexylamide

Versuchsvorschrift

The title compound is prepared according to the reaction sequence 3.01a-2.01b described above using 1-(tert-butoxycarbonyl)-4-fluoropiperidine-4-carboxylic acid instead of 1-(tert-butoxycarbonyl)-piperidine-4-carboxylic acid and cyclohexylamine as in 3.01a: LC-MS A: tR=0.49 min; [M+H]+=229.25.

Quellen und Nachweise

ORD-Eintrag
ord-a602ce92eed647648d6b9531ff0a0e0a
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428456B2

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