4-Chloropyridine-2-carbaldehyde → 1-(4-Chloro-pyridin-2-ylmethyl)-piperidine-4-carboxylic acid cyclohexylamide

HRID 1486736Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1486736
[Cl:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=O)[CH:3]=1.Cl.[CH:11]1([NH:17][C:18]([CH:20]2[CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)=[O:19])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1>>[CH:11]1([NH:17][C:18]([CH:20]2[CH2:21][CH2:22][N:23]([CH2:8][C:4]3[CH:3]=[C:2]([Cl:1])[CH:7]=[CH:6][N:5]=3)[CH2:24][CH2:25]2)=[O:19])[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]1

Komponenten

3

Edukt 2

HCID 27631664-Chloropyridine-2-carbaldehydeHCID 44630870N-cyclohexylpiperidine-4-carboxamide hydrochloride

Produkt 1

HCID 867065541-(4-Chloro-pyridin-2-ylmethyl)-piperidine-4-carboxylic acid cyclohexylamide

Versuchsvorschrift

The title compound is prepared according to the reaction 3.01c described above using 4-chloro-pyridine-2-carboxaldehyde and piperidine-4-carboxylic acid cyclohexylamide hydrochloride as in 3.01c: LC-MS A: tR=0.58 min; [M+H]+=380.19.

Quellen und Nachweise

ORD-Eintrag
ord-453df22e3b924ff88db85099ff945b37
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428456B2

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