Hydrogen Peroxide → 4-Chloro-3,5-bis(trifluoromethyl)benzamide

HRID 1487007Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487007
[Cl:1][C:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][C:5]([C:6]#[N:7])=[CH:4][C:3]=1[C:14]([F:17])([F:16])[F:15].C([O-])([O-])=[O:19].[K+].[K+].OO>CS(C)=O>[Cl:1][C:2]1[C:3]([C:14]([F:15])([F:16])[F:17])=[CH:4][C:5]([C:6]([NH2:7])=[O:19])=[CH:8][C:9]=1[C:10]([F:11])([F:12])[F:13]

Komponenten

5

Edukt 3

HCID 784Hydrogen PeroxideHCID 11430Potassium CarbonateHCID 226251933,5-Bis(trifluoromethyl)-4-chlorobenzonitrile

Produkt 1

HCID 867303704-Chloro-3,5-bis(trifluoromethyl)benzamideAusbeute 93,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

4-Chloro-3,5-bis(trifluoromethyl)benzonitrile (1 g, 1.0 eq.) was dissolved in DMSO (10 mL). K2CO3 (0.55 g, 1.1 eq.) and H2O2 (1 mL) were added to the reaction mixture and stirred at room temperature for 2-3 h, then poured into ice water (20 mL). The precipitate formed was collected by filtration and washed with petroleum ether to afford 1.0 g of crude product (90% yield), which was used without further purification in the next step.

Aufarbeitung

  1. customThe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with petroleum ether

Quellen und Nachweise

ORD-Eintrag
ord-00da5095a4d148659b177c1fa89bca13
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428490B2

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