HCID 71250748, Verbindung → tert-butyl N-[(3-fluoroazetidin-3-yl)methyl]carbamate

HRID 1487012Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487012
C([N:14]1[CH2:17][C:16]([CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:26])([CH3:25])[CH3:24])([F:18])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1>C(O)C.[OH-].[OH-].[Pd+2]>[F:18][C:16]1([CH2:19][NH:20][C:21](=[O:27])[O:22][C:23]([CH3:25])([CH3:24])[CH3:26])[CH2:15][NH:14][CH2:17]1

Komponenten

4

Edukt 1

HCID 71250748HCID 71250748, Verbindung

Produkt 1

HCID 71250747tert-butyl N-[(3-fluoroazetidin-3-yl)methyl]carbamateAusbeute 72,5 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

tert-Butyl (1-benzhydryl-3-fluoroazetidin-3-yl)methylcarbamate (0.6 g, 1.35 mmol) was dissolved in ethanol and Pd(OH)2 (0.38 gm, 2.7 mmol) was added. The reaction mixture was stirred at rt for 14 h under H2 atmosphere. The solids were removed by filtration and the filtrate was concentrated under reduced pressure to afford 0.2 g of tert-butyl (3-fluoroazetidin-3-yl)methylcarbamate (66% yield).

Aufarbeitung

  1. customThe solids were removed by filtration
  2. concentrationthe filtrate was concentrated under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-486d9d02e9e9469a8587e39d9d13a412
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428490B2

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