Ammonia → HCID 89815111, Verbindung

HRID 1487115Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487115
[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3](OCC)=[O:4].[NH3:18]>>[F:1][C:2]([F:17])([C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([N+:14]([O-:16])=[O:15])[CH:9]=1)[C:3]([NH2:18])=[O:4]

Komponenten

3

Edukt 2

HCID 222AmmoniaHCID 53419335Benzeneacetic acid, α,α-difluoro-3-nitro-, ethyl ester

Produkt 1

HCID 89815111HCID 89815111, Verbindung

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

A solution of ethyl 2,2-difluoro-2-(3-nitrophenyl)acetate (0.701 g, 2.86 mmol) in Methanolic ammonia (7M, 20.0 ml) was taken in sealed tube. Resulting mixture was heated at 75° C. for 3 hrs. The reaction mixture was concentrated under vacuum and cold water was added to obtain the precipitate. Solid was filtered to obtain 2,2-difluoro-2-(3-nitrophenyl)acetamide (0.515 g).

Aufarbeitung

  1. customResulting mixture
  2. concentrationThe reaction mixture was concentrated under vacuum and cold water
  3. additionwas added
  4. customto obtain the precipitate
  5. filtrationSolid was filtered

Quellen und Nachweise

ORD-Eintrag
ord-8c95057f9b114a829ccbb2c6e29538df
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428499B2

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