Sodium Hydroxide → 1,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

HRID 1487272Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487272
C[O:2][C:3]([C:5]1[CH:10]=[C:9]([CH3:11])[C:8](=[O:12])[N:7]([CH3:13])[CH:6]=1)=[O:4].[OH-].[Na+]>CO>[CH3:13][N:7]1[C:8](=[O:12])[C:9]([CH3:11])=[CH:10][C:5]([C:3]([OH:4])=[O:2])=[CH:6]1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 117889483Methyl 1,5-dimethyl-6-oxopyridine-3-carboxylate

Produkt 1

HCID 218859251,5-Dimethyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

1,5-Dimethyl-6-oxo-1,6-dihydro-pyridine-3-carboxylic acid methyl ester C-1 (2.60 g; 14.35 mmol) is suspended in MeOH. Sodium hydroxide (1 M solution, 45 ml; 45.00 mmol) is added and the reaction mixture is heated up to 100° C. (Drysyn, reflux) for 2 h. MeOH is removed under reduced pressure and 1N HCl (46 ml) is added to the solution, precipitation occurs. The precipitate is filtered off and dried under reduced pressure.

Aufarbeitung

  1. temperature(Drysyn, reflux) for 2 h
  2. customMeOH is removed under reduced pressure and 1N HCl (46 ml)
  3. additionis added to the solution, precipitation
  4. filtrationThe precipitate is filtered off
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-0c64059cd1764151813a7a7f79d8bb53
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428515B2

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