Hydrochloric Acid → 4-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)

HRID 1487814Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487814
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1)#[N:2].[ClH:22]>C(OCC)(=O)C>[ClH:22].[NH:12]1[CH2:13][CH2:14][CH:9]([C:6]2[CH:7]=[CH:8][C:3]([C:1]#[N:2])=[CH:4][CH:5]=2)[CH2:10][CH2:11]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 22492960Tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate2×

Produkt 1

HCID 193916184-(Piperidin-4-yl)benzonitrile--hydrogen chloride (1/1)Ausbeute 57 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

Into a 500-mL three neck round-bottom flask, was placed a solution of tert-butyl 4-(4-cyanophenyl)piperidine-1-carboxylate (compound 1.1, 20 g, crude) in ethyl acetate (200 mL). Hydrogen chloride (gas) was introduced to the solution and the resulting mixture was stirred for 30 min at room temperature. The solids were collected by filtration, then washed with ethyl acetate (100 mL) and ether (100 mL) to yield the title compound as a white solid (14 g, 57% over two steps).

Aufarbeitung

  1. filtrationThe solids were collected by filtration
  2. washwashed with ethyl acetate (100 mL) and ether (100 mL)

Quellen und Nachweise

ORD-Eintrag
ord-a799ca846b054023849e06efd76ff7ed
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428502B2

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