Chlorosuccinimide → HCID 178494680, Verbindung
Reaktionsgleichung
[CH3:1][O:2][CH2:3][C:4]1[NH:5][C:6]([C:9]2[CH:10]=[C:11]([CH:16]=[CH:17][C:18]=2[CH3:19])[C:12]([O:14][CH3:15])=[O:13])=[CH:7][N:8]=1.C1C(=O)N([Cl:27])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Cl:27][C:7]1[N:8]=[C:4]([CH2:3][O:2][CH3:1])[NH:5][C:6]=1[C:9]1[CH:10]=[C:11]([CH:16]=[CH:17][C:18]=1[CH3:19])[C:12]([O:14][CH3:15])=[O:13]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Reaktionsbedingungen
- Temperatur
- 50 °C
Versuchsvorschrift
Into a 50-mL round-bottom flask, which was purged and maintained with an inert atmosphere of nitrogen, was placed a solution of methyl 3-(2-(methoxymethyl)-1H-imidazol-5-yl)-4-methylbenzoate (compound 27.3, 40 mg, 0.15 mmol) and NCS (24.6 mg, 0.18 mmol) in CCl4 (20 mL). The resulting mixture was stirred for 2 h at 50° C., then cooled to room temperature and quenched with water (100 mL). The aqueous phase was extracted with ethyl acetate (100 mL) and the combined organic layers were washed with brine (3×30 mL), dried (Na2SO4), filtered, and concentrated under reduced pressure to yield 30 mg (crude) of the title compound as a yellow solid.
Aufarbeitung
- customInto a 50-mL round-bottom flask, which was purged
- temperaturemaintained with an inert atmosphere of nitrogen
- temperaturecooled to room temperature
- customquenched with water (100 mL)
- extractionThe aqueous phase was extracted with ethyl acetate (100 mL)
- washthe combined organic layers were washed with brine (3×30 mL)
- dry with materialdried (Na2SO4)
- filtrationfiltered
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-70fa8efbc7a44b7aaa812d9671d1a937
- Quelldatensatz
- uspto-grants-2016_08
- Patentnummer
- US09428502B2
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