Sodium Sulfite → HCID 178506557, Verbindung

HRID 1487907Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1487907
S([O-])([O-])=O.[Na+].[Na+].[CH:7]1([C:10]2[NH:11][C:12]([I:16])=[C:13](I)[N:14]=2)[CH2:9][CH2:8]1>O.CCO>[CH:7]1([C:10]2[NH:14][CH:13]=[C:12]([I:16])[N:11]=2)[CH2:9][CH2:8]1

Komponenten

4

Edukt 2

HCID 24437Sodium SulfiteHCID 219853952-Cyclopropyl-4,5-diiodo-1h-imidazole2×

Produkt 1

HCID 178506557HCID 178506557, VerbindungAusbeute 73 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 19096565Water ethanolLösungsmittel

Versuchsvorschrift

Into a 100-mL round-bottom flask, was placed a solution of sodium sulfite (11.3 g, 89.7 mmol) in H2O/EtOH (30/15 mL). 2-Cyclopropyl-4,5-diiodo-1H-imidazole (compound 44.2, 3.8 g, 10.6 mmol) was added and the resulting solution was heated at reflux overnight. The reaction was cooled and the volatiles were removed under reduced pressure. The solids were collected by filtration to yield 1.8 g (73%) of the title compound as a light brown solid.

Aufarbeitung

  1. customInto a 100-mL round-bottom flask, was placed
  2. temperaturethe resulting solution was heated
  3. temperatureat reflux overnight
  4. temperatureThe reaction was cooled
  5. customthe volatiles were removed under reduced pressure
  6. filtrationThe solids were collected by filtration

Quellen und Nachweise

ORD-Eintrag
ord-40c00c885e4c4470b4c3496d9af718c4
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428502B2

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