[CH3:1][C:2]1[NH:3][C:4]([C:8]2[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=2[CH3:17])[C:11]([OH:13])=[O:12])=[C:5]([CH3:7])[N:6]=1.IC1NC(C2(C)[CH2:29][CH2:28][N:27]([C:30]([O:32][C:33]([CH3:36])([CH3:35])[CH3:34])=[O:31])[CH2:26][CH2:25]2)=NC=1C.I[C:40]1NC(C)=NC=1C>>[C:33]([O:32][C:30]([N:27]1[CH2:28][CH2:29][C:1]([C:2]2[NH:3][C:4]([C:8]3[CH:9]=[C:10]([CH:14]=[CH:15][C:16]=3[CH3:17])[C:11]([OH:13])=[O:12])=[C:5]([CH3:7])[N:6]=2)([CH3:40])[CH2:25][CH2:26]1)=[O:31])([CH3:36])([CH3:35])[CH3:34]The title compound was prepared using standard chemical manipulations and procedures similar to those used for the preparation of compound 5.7, except tert-butyl 4-(5-iodo-4-methyl-1H-imidazol-2-yl)-4-methylpiperidine-1-carboxylate (compound 185.1) was used in place of 5-iodo-2,4-dimethyl-1H-imidazole (compound 5.5).
Wird geladen…