Chlorosuccinimide → HCID 178494718, Verbindung

HRID 1488184Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1488184
[CH3:1][O:2][CH2:3][C:4]1[CH:8]=[CH:7][NH:6][N:5]=1.C1C(=O)N([Cl:16])C(=O)C1>C(Cl)(Cl)Cl>[Cl:16][C:8]1[C:4]([CH2:3][O:2][CH3:1])=[N:5][NH:6][CH:7]=1

Komponenten

4

Edukt 2

HCID 31398ChlorosuccinimideHCID 178494540HCID 178494540, Verbindung2×

Produkt 1

HCID 178494718HCID 178494718, VerbindungAusbeute 19,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6212ChloroformLösungsmittel

Versuchsvorschrift

To a solution of 3-(methoxymethyl)-1H-pyrazole (compound 281.1, 200 mg, 1.78 mmol) in chloroform (20 mL) was added NCS (237 mg, 1.77 mmol). The reaction mixture was stirred overnight at room temperature, then quenched with 20 mL of H2O. The aqueous phase was extracted with 3×50 mL of ethyl acetate. The combined organic layers were washed with 3×20 mL of brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel chromatography with EtOAc:PE (1:2) as the eluent to furnish 50 mg (19%) of the title compound as a white solid.

Aufarbeitung

  1. customquenched with 20 mL of H2O
  2. extractionThe aqueous phase was extracted with 3×50 mL of ethyl acetate
  3. washThe combined organic layers were washed with 3×20 mL of brine
  4. dry with materialdried over anhydrous sodium sulfate
  5. concentrationconcentrated under reduced pressure
  6. customThe residue was purified by silica gel chromatography with EtOAc

Quellen und Nachweise

ORD-Eintrag
ord-625529f58bc14adaa5877ab9de540ae9
Quelldatensatz
uspto-grants-2016_08
Patentnummer
US09428502B2

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