Methyl acetoacetate → Methyl 2-[(dimethylamino)methylene]acetoacetate
Reaktionsgleichung
[O:1]=[C:2]([CH3:8])[CH2:3][C:4]([O:6][CH3:7])=[O:5].CO[CH:11]([N:14]([CH3:16])[CH3:15])OC>>[CH3:11][N:14](/[CH:16]=[C:3](/[C:2](=[O:1])[CH3:8])\[C:4]([O:6][CH3:7])=[O:5])[CH3:15]Komponenten
3
Reaktionsbedingungen
- Temperatur
- 80 °C
Versuchsvorschrift
Into a 250-mL round-bottom flask, was placed methyl 3-oxobutanoate (10.8 g, 92.6 mmol) and (dimethoxymethyl)dimethylamine (12.7 mL, 95.3 mmol). The resulting solution was stirred for 2.5 h at 80° C., then concentrated under reduced pressure to yield 14.5 g (crude) of the title compound as a red solid.
Aufarbeitung
- customInto a 250-mL round-bottom flask, was placed
- concentrationconcentrated under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-63f9962e09584cef8fb23b8ceb188d07
- Quelldatensatz
- uspto-grants-2016_08
- Patentnummer
- US09428502B2
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