Sodium Chloride → HCID 22877891, Verbindung

(Z)-1-(3-Amino-4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)-ethene-Fmoc-L-serineamide (1.04 g, 1.56 mmols) was dissolved in 10 ml of methanol and 10 ml of dichloromethane, and 1.7 ml (3.4 mmols) of an aqueous solution of 2-N sodium hydroxide were added thereto. The mixture was stirred at room temperature for 24 hours. A saturated aqueous solution of sodium chloride was added thereto, and the resulting mixture was extracted three times with dichloromethane. The extract was dried over anhydrous sodium sulfate, and concentrated to dryness under reduced pressure. The product was purified using a silica-gel plate (mixture of 5-% by volume methanol and dichloromethane) to produce 315 mg of the final compound in a yield of 50.2%.

1. extractionthe resulting mixture was extracted three times with dichloromethane
2. dry with materialThe extract was dried over anhydrous sodium sulfate
3. concentrationconcentrated to dryness under reduced pressure
4. customThe product was purified
5. additiona silica-gel plate (mixture of 5-% by volume methanol and dichloromethane)

ORD-Eintrag

ord-a6872ad0623d4948b33828b1a8306796

Quelldatensatz

uspto-grants-1997_10

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US05674906