Methyl alpha-cyclohexyl-alpha-hydroxybenzeneacetate → 4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Methyl alpha-cyclohexyl-alpha-hydroxybenzeneacetate	HCID 112035	—
Edukt	4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-yn-1-ol	HCID 4248190	—
Edukt	Sodium Methoxide	HCID 10942334	—
Lösungsmittel	Toluene	HCID 1140	—
Produkt	4-[Ethyl-[(4-methoxyphenyl)methyl]amino]but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate	HCID 5044225	—

Reaktionsschritte

reacting a single enantiomer of methyl α-cyclohexyl-α-hydroxybenzeneacetate (IV) with 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butyn-1-ol (V) in the presence of a catalytic amount of sodium methoxide in toluene to produce a single enantiomer of 4-[N-ethyl-(4-methoxyphenyl)methylamino]-2-butynyl α-cyclohexyl-α-hydroxybenzeneacetate (VI); and

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05677346
Quelldatensatz	uspto-grants-1997_10
ORD ID	ord-06c8c46dc4e34a24b045809eb93a19f6
Quellennotiz	uspto-grants-1997_10