Thionyl Chloride → 3-(2-Biphenylyl)-2-ethylpropionyl chloride

HRID 1489313

Reaktionsgleichung

Reaktionsgleichung von HRID 1489313
[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9](O)=[O:10].S(Cl)([Cl:22])=O>>[C:1]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][CH:8]([CH2:12][CH3:13])[C:9]([Cl:22])=[O:10]

Komponenten

3

Edukt 2

HCID 24386Thionyl ChlorideHCID 215719833-(2-Biphenylyl)-2-ethylpropionic acid

Produkt 1

HCID 223402173-(2-Biphenylyl)-2-ethylpropionyl chlorideAusbeute 106,3 %

Versuchsvorschrift

To a 100-ml three-necked round flask (equipped with stirrer chip, Dimroth condenser, thermometer and NaOH trap) were introduced 13.3 g (52.4 mmol) of the 3-(2-biphenylyl)-2-ethylpropionic acid and 25.9 ml (355 mmol) of thionyl chloride, and they were refluxed for 2.5 hours with heating in a nitrogen atmosphere. After the reaction was completed, the unreacted thionyl chloride was distilled off under reduced pressure to obtain 15.2 g of a crude product of yellow orange liquid. This acid chloride was used for the next reaction without further purification. The properties of the product thus obtained are described below.

Aufarbeitung

  1. customTo a 100-ml three-necked round flask (equipped with stirrer chip, Dimroth condenser
  2. temperaturewere refluxed for 2.5 hours
  3. temperaturewith heating in a nitrogen atmosphere
  4. distillationthe unreacted thionyl chloride was distilled off under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-ca9642abf1f94eaca83a79f5b40c43cb
Quelldatensatz
uspto-grants-1997_10
Patentnummer
US05677408

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