Phosphorus oxychloride → HCID 18184384, Verbindung

HRID 1489581Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1489581
O=[C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH2:13][NH:14][CH:3]12.O=P(Cl)(Cl)[Cl:17]>>[Cl:17][C:2]1[C:11]2[N:10]=[CH:9][N:8]=[CH:7][C:6]=2[CH:5]=[C:4]2[O:12][CH:13]=[N:14][C:3]=12

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 69704031HCID 69704031, Verbindung

Produkt 1

HCID 18184384HCID 18184384, VerbindungAusbeute 22 %

Versuchsvorschrift

A suspension of 4-oxo-3H-oxazolo[5,4-g]quinazoline (0.98 g, 5.24 mmol) in POCl3 (30 mL) is heated under reflux with vigorous stirring for 18 h, and then concentrated to dryness. The residue is partitioned between EtOAc and saturated aqueous NaHCO3 and the organic portion is worked up to give 4-chlorooxazolo[5,4-g]quinazoline (0.24g, 22%) as a yellow solid which is used directly.

Aufarbeitung

  1. temperatureis heated
  2. temperatureunder reflux
  3. concentrationconcentrated to dryness
  4. customThe residue is partitioned between EtOAc and saturated aqueous NaHCO3

Quellen und Nachweise

ORD-Eintrag
ord-203efed6d462496aa462c4202abd6283
Quelldatensatz
uspto-grants-1997_10
Patentnummer
US05679683

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