HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Tert-Butylamine → tert-Butyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Tert-Butylamine | HCID 6385 | — |
| Edukt | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | — |
| Produkt | tert-Butyl-[3-(2-chloro-pyrimidin-4-yl)-benzyl]-amine | HCID 86603310 | 97% |
Reaktionsschritte
3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde (intermediate 1) and tert butylamine were coupled by procedure B. The yield was 97%. LC-MS showed the product had the expected M+H+ of 276. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 8.6 (d, 1H) 8.1 (s, 1H) 7.9 (d, 1H) 7.6 (d, 1H) 7.5 (m, 2H) 1.2 (s, 9H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732444B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-4b4178151fca419dac819ae8ff154559 |
| Quellennotiz | uspto-grants-2010_06 |