HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1491494Erstellt: 26. Oktober 2026
1-(2-Methoxyphenyl)isoquinoline → 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline
https://huagongshe.com/reaction/1491494
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 1-(2-Methoxyphenyl)isoquinoline | HCID 23159734 | — |
| Reagenz | Bis(pinacolato)diborane | HCID 2733548 | — |
| Reagenz | 4,4,5,5-Tetramethyl[1,3,2]dioxaborolane | HCID 2734768 | — |
| Reagenz | N,N-Dibenzyl-N'-(pyridin-2-ylmethylene)hydrazine | HCID 67601456 | — |
| Katalysator | Bis(1,5-cyclooctadiene)dimethoxydiiridium | HCID 76001521 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | 1-[2-Methoxy-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]isoquinoline | HCID 101547938 | 88% |
Reaktionsschritte
Following the general procedure, precipitation from the reaction crude with hexane and trituration afforded 9i (159 mg, 88 %) as a pale solid.
Herkunft & Nachweise
| DOI | 10.1002/anie.201104544 |
|---|
| Quelldatensatz | Borylation dataset from Roche |
|---|
| ORD ID | ord-2dd73b1c305947e1a593c90545f7d2d2 |
|---|
| Quellennotiz | Borylation dataset from Roche |
|---|
