N-methyl-5-nitropyridin-2-amine → N2-Methylpyridine-2,5-diamine
Reaktionsgleichung
[N+:1]([C:4]1[CH:5]=[N:6][C:7]([NH:10][CH3:11])=[CH:8][CH:9]=1)([O-])=O.[H][H]>[Pt]=O.C(O)C>[NH2:1][C:4]1[CH:5]=[N:6][C:7]([NH:10][CH3:11])=[CH:8][CH:9]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
To 40 ml of an ethanol solution of the methylamino compound (4 g) obtained in (a) described above was added, 400 mg of platinum oxide, followed by reaction in an atmosphere of hydrogen at room temperature for 15 hours. The solvent was thereafter removed by distillation, and the residue was purified by silica gel column chromatography (eluent: chloroform, and subsequently chloroform: methanol=20:1 (v/v)) to obtain 320 mg of the intended product as brown crystals.
Aufarbeitung
- additionabove was added
- customThe solvent was thereafter removed by distillation
- customthe residue was purified by silica gel column chromatography (eluent
Quellen und Nachweise
- ORD-Eintrag
- ord-38f62494eb534c888addf8aa145dae27
- Quelldatensatz
- uspto-grants-1994_12
- Patentnummer
- US05371086
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