[CH2:1]([NH:4][C:5](=[O:9])[O:6][CH2:7][CH3:8])[C:2]#[CH:3].[OH-].[K+].Cl[CH2:13][C:14]1[N:19]=[CH:18][CH:17]=[CH:16][N:15]=1>[Cl-].C([N+](CC)(CC)CC1C=CC=CC=1)C.C1(C)C=CC=CC=1>[CH2:7]([O:6][C:5]([N:4]([CH2:13][C:14]1[N:19]=[CH:18][CH:17]=[CH:16][N:15]=1)[CH2:1][C:2]#[CH:3])=[O:9])[CH3:8]11.5 g (91 mmol) of ethyl N-propargylcarbamate are introduced into 90 ml of toluene, 20.3 g of KOH powder and 0.5 g of triethylbenzylammonium chloride are added, and 13.5 g (104 mmol) of 2-chloromethyl-pyrimidine (German Offenlegungsschrift 2,932,643) are added dropwise at room temperature. The mixture is stirred overnight at room temperature, the salts are filtered off with suction, the filtrate is washed using saturated sodium chloride solution, dried over magnesium sulphate and concentrated, and the concentrate is distilled.
Wird geladen…
