6-Methoxy-9H-purine → (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	6-Methoxy-9H-purine	HCID 70632	—
Edukt	(1S)-[(2R)-(2,4-difluorophenyl)-2-oxiranyl]ethanol	HCID 10631861	—
Edukt	(2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-7(7H)-purinyl]ethyl]oxirane	HCID 22859142	—
Produkt	(2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane	HCID 18657628	21,1%

Reaktionsschritte

Using (1S)-1-[(2R)-2-(2,4-difluorophenyl)-2-oxiranyl] ethanol (523 mg) and 6-methoxypurine 1/2 hydrate (415 mg), (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-7(7H)-purinyl]ethyl]oxirane (205 mg) and (2S)-2-(2,4-difluorophenyl)-2-[(1R)-1-[6-methoxy-9(9H)-purinyl]ethyl] oxirane (183 mg) were obtained as a white powder respectively by the same way as in Reference Example 2.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US05371100
Quelldatensatz	uspto-grants-1994_12
ORD ID	ord-8952cc44ae7a4c39a6e4a34b12fe23cc
Quellennotiz	uspto-grants-1994_12