6-(Hydroxymethyl)pyridine-2-carboxamide → 6-Formylpicolinamide

HRID 1491821Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1491821
[OH:1][CH2:2][C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1>C(Cl)(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH:2]([C:3]1[N:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][CH:4]=1)=[O:1]

Komponenten

4

Edukt 1

HCID 149169816-(Hydroxymethyl)pyridine-2-carboxamide

Produkt 1

HCID 189539186-FormylpicolinamideAusbeute 61,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 178418406HCID 178418406, VerbindungKatalysatorHCID 6212ChloroformLösungsmittel

Versuchsvorschrift

A mixture of 6-hydroxymethyl-2-pyridinecarboxamide (100 g) and manganese dioxide (500 g) in chloroform (2 l) was heated under reflux for 48 hours. Manganese dioxide was removed by filtration and the filtrate was evaporated in vacuo to give 6-formyl-2-pyridinecarboxamide (60.46 g).

Aufarbeitung

  1. temperaturewas heated
  2. temperatureunder reflux for 48 hours
  3. customManganese dioxide was removed by filtration
  4. customthe filtrate was evaporated in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-0d14b8dd3316448dab3144b334b45322
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05371097

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