Ethanol → Ethyl 5-benzyloxypentanoate

HRID 1491998Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1491998
[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([OH:15])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:16](O)[CH3:17].S(=O)(=O)(O)O>C(N(CC)CC)C>[CH2:1]([O:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 104205755-(Benzyloxy)pentanoic acid

Produkt 1

HCID 18953758Ethyl 5-benzyloxypentanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

A mixture of 61.1 g of 5-benzyloxypentanoic acid, 566 ml of ethanol and 10 ml of concentrated sulfuric acid is refluxed for 15 h. The mixture is cooled to room temperature, 10 ml of triethylamine are added and evaporated. The residue is diluted with 250 ml of ether and the solution is washed in water and brine dried (MgSO4) and evaporated. The residual oil is distilled to give ethyl 5-benzyloxypentanoate, b.p. 110°-113° C. (0.7 mm/Hg).

Aufarbeitung

  1. temperatureis refluxed for 15 h
  2. customevaporated
  3. additionThe residue is diluted with 250 ml of ether
  4. washthe solution is washed in water
  5. dry with materialbrine dried (MgSO4)
  6. customevaporated
  7. distillationThe residual oil is distilled

Quellen und Nachweise

ORD-Eintrag
ord-6690fe47460a4ce08d4c3bc3fbdb9b2d
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05371096

Notizen zur Reaktion

Wird geladen…