Isobutyronitrile → N-(2-morpholinophenyl)isobutyramidine

HRID 1492185

Reaktionsgleichung

Reaktionsgleichung von HRID 1492185
Cl.[NH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1.[C:15](#[N:19])[CH:16]([CH3:18])[CH3:17]>>[O:12]1[CH2:13][CH2:14][N:9]([C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[NH:2][C:15](=[NH:19])[CH:16]([CH3:18])[CH3:17])[CH2:10][CH2:11]1

Komponenten

3

Edukt 2

HCID 6559IsobutyronitrileHCID 189522842-Morpholinoaniline hydrochloride

Produkt 1

HCID 178449872N-(2-morpholinophenyl)isobutyramidine

Reaktionsbedingungen

Temperatur
165 °C

Versuchsvorschrift

A mixture of 4-(2-aminophenyl)morpholine hydrochloride (10 g) and isobutyronitrile (60 ml) was heated at 165° C. for 26 hours in a sealed stainless steel pressure vessel to yield N-(2-morpholinophenyl)isobutyramidine (m.p. 140°-141° C.) which was recrystallised from hexane.

Quellen und Nachweise

ORD-Eintrag
ord-030dc84115224d40a2f2a3b18cc66c49
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05373008

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