Methanol → HCID 18398665, Verbindung
Reaktionsgleichung
[S:1]1[C:9]2[C:4](=[N:5][C:6]([C:10]([OH:12])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1.[CH3:13]O>>[S:1]1[C:9]2[C:4](=[N:5][C:6]([C:10]([O:12][CH3:13])=[O:11])=[CH:7][CH:8]=2)[CH:3]=[CH:2]1Komponenten
3
Versuchsvorschrift
To a cold solution of HCI (10%) in MeOH (10 mL) was added thieno[3,2-b]pyridine-5-carboxylic acid (1.0 g, 5.6 mmol, and the mixture heated to reflux for 2 hr. After cooling to r.t., half the solvent was removed by evaporation and the remainder was partitioned between EtOAc and H2O. Solid NaHCO3 was added until the system remained basic. Separation, drying and evaporation of the organic layer afforded 0.75 g (70%) of the title compound.
Aufarbeitung
- temperaturethe mixture heated
- temperatureto reflux for 2 hr
- customhalf the solvent was removed by evaporation
- customthe remainder was partitioned between EtOAc and H2O
- additionSolid NaHCO3 was added until the system
- customSeparation
- customdrying
- customevaporation of the organic layer
Quellen und Nachweise
- ORD-Eintrag
- ord-301a2bc90a0d4924ac59dedc883be5da
- Quelldatensatz
- uspto-grants-1994_12
- Patentnummer
- US05374635
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