2,6-Dimethyl-8-ethyl-1-deazapurine → HCID 19385593, Verbindung
Reaktionsgleichung
[Si:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13]Br)=[CH:11][C:10]=1[Cl:17])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:18][C:19]1[N:24]=[C:23]2[N:25]=[C:26]([CH2:28][CH3:29])[NH:27][C:22]2=[C:21]([CH3:30])[CH:20]=1>>[Si:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH2:13][N:25]2[C:23]3=[N:24][C:19]([CH3:18])=[CH:20][C:21]([CH3:30])=[C:22]3[N:27]=[C:26]2[CH2:28][CH3:29])=[CH:11][C:10]=1[Cl:17])([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]Komponenten
3
Versuchsvorschrift
The product of Step C (1.79 g, 5.15 mmol) was used to alkylate 0.750 g (4.29 mmol) of 5,7-dimethyl-2-ethylimidazo[4,5-b]-pyridine (prepared as described in EP 400,974 published Dec. 5, 1990) according to the procedure described for Step B of Example 2, which after purification afforded 0.294 g (15%) of the title compound.
Aufarbeitung
- customafter purification