Triethylamine → HCID 178470392, Verbindung

HRID 1492768Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1492768
Cl.[NH2:2][CH:3]([C:9](=O)[CH3:10])[C:4]([O:6][CH2:7][CH3:8])=[O:5].[C:12](=[NH:17])(OCC)[CH3:13].C(N(CC)CC)C>C(O)C>[CH3:13][C:12]1[NH:2][C:3]([C:4]([O:6][CH2:7][CH3:8])=[O:5])=[C:9]([CH3:10])[N:17]=1

Komponenten

5

Edukt 3

HCID 8471TriethylamineHCID 65066Ethyl acetimidateHCID 13282897Ethyl 2-amino-3-oxobutanoate hydrochloride

Produkt 1

HCID 178470392HCID 178470392, VerbindungAusbeute 23,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

Ethyl 2-amino-3-oxobutanoate hydrochloride (5 g) was added portionwise to a solution of ethyl ethaneimidate (34.0 g) and triethylamine (42 ml) in ethanol (500 ml), and the resulting yellow solution was stirred overnight. Solvent was removed in vacuo and the residue partitioned between water (200 ml) and ether (200 ml). The organic layer was separated and the aqueous phase further extracted with ether (2×200 ml). The dried organic extracts were evaporated in vacuo and the residue washed with cold ether and filtered to give the title compound as a white solid (1.1 g). m.p. 165-166° C.

Aufarbeitung

  1. customSolvent was removed in vacuo
  2. customthe residue partitioned between water (200 ml) and ether (200 ml)
  3. customThe organic layer was separated
  4. extractionthe aqueous phase further extracted with ether (2×200 ml)
  5. customThe dried organic extracts were evaporated in vacuo
  6. washthe residue washed with cold ether
  7. filtrationfiltered

Quellen und Nachweise

ORD-Eintrag
ord-dbf3f6160cac4904851a06223061e42a
Quelldatensatz
uspto-grants-1994_12
Patentnummer
US05374646

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