Hydrochloric Acid → HCID 178493552, Verbindung

HRID 1493091Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1493091
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][NH2:12])[N:4]=1.[ClH:13].[N:14]#[C:15][NH2:16]>C(O)C>[ClH:13].[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([NH:11][NH:12][C:15]([NH2:16])=[NH:14])[N:4]=1

Komponenten

5

Edukt 3

HCID 313Hydrochloric AcidHCID 9864CyanamideHCID 144790742-Hydrazinyl-4,6-dimethoxypyrimidine

Produkt 1

HCID 178493552HCID 178493552, VerbindungAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture of 17.0 g (0.1 mol) of 4,6-dimethoxy-2-hydrazino-pyrimidine, 8.3 ml of concentrated hydrochloric acid, 4.2 g (0.1 mol) of cyanamide and 100 ml of ethanol is boiled to reflux for 18 hours. The mixture is then evaporated, the residue is crystallized using diethyl ether, and the crystalline product is isolated by filtering off with suction. 22.9 g (92% of theory) of (4,6-dimethoxy-pyrimidin-2-yl-amino)-guanidine hydrochloride of melting point 214° C. are obtained.

Aufarbeitung

  1. temperatureto reflux for 18 hours
  2. customThe mixture is then evaporated
  3. customthe residue is crystallized
  4. customthe crystalline product is isolated
  5. filtrationby filtering off with suction

Quellen und Nachweise

ORD-Eintrag
ord-7001074c92aa4970aee78a943d85a89a
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05021082

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