HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Thiopheneethanamine → (4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-yl)-(2-thiophen-2-yl-ethyl)-amine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Thiopheneethanamine | HCID 116521 | — |
| Edukt | 4-{[3-(2-Chloro-pyrimidin-4-yl)-benzyl]-ethyl-amino}-piperidine-1-carboxylic acid tert-butyl ester | HCID 86603290 | — |
| Produkt | (4-{3-[(Ethyl-piperidin-4-yl-amino)-methyl]-phenyl}-pyrimidin-2-yl)-(2-thiophen-2-yl-ethyl)-amine | HCID 58603588 | — |
Reaktionsschritte
Intermediate 84 was coupled with 2-thiophen-2-yl-ethylamine following procedure F. The product was deprotected following procedure G2. LC-MS showed the product had the expected M+H+ of 422.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07732444B2 |
| Quelldatensatz | uspto-grants-2010_06 |
| ORD ID | ord-0da0f5fd3bec4c559704afb8fa2e8a8c |
| Quellennotiz | uspto-grants-2010_06 |