N-CHLOROMETHYL-N-PHENYLCARBAMOYL CHLORIDE → HCID 14801070, Verbindung

HRID 1493199Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1493199
Cl[CH2:2][N:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4](Cl)=[O:5].[Cl:13][C:14]1[CH:15]=[C:16]([CH:27]=[CH:28][C:29]=1[Cl:30])[CH2:17][NH:18][C:19]([NH:21][CH2:22][C:23]([F:26])([F:25])[F:24])=[S:20]>C1C=CC=CC=1>[F:26][C:23]([F:24])([F:25])[CH2:22][N:21]=[C:19]1[N:18]([CH2:17][C:16]2[CH:27]=[CH:28][C:29]([Cl:30])=[C:14]([Cl:13])[CH:15]=2)[C:4](=[O:5])[N:3]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[CH2:2][S:20]1

Komponenten

4

Edukt 2

HCID 11241146N-CHLOROMETHYL-N-PHENYLCARBAMOYL CHLORIDEHCID 14801046HCID 14801046, Verbindung

Produkt 1

HCID 14801070HCID 14801070, VerbindungAusbeute 40,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 241BenzeneLösungsmittel2×

Versuchsvorschrift

1.00 g of N-chloromethyl-N-phenylcarbamoyl chloride and 1.55 g of 1-(3,4-dichlorobenzyl)-3-(2,2,2-trifluoroethyl)thiourea were dissolved in 30 m1 of benzene, and the solution was heated under reflux. After the reaction, benzene was evaporated under reduced pressure. The resulting oily product was purified by column chromatography silica gel; eluent: hexane/ethyl acetate (10/1)] to give 0.88 g of the captioned compound.

Aufarbeitung

  1. temperaturethe solution was heated
  2. temperatureunder reflux
  3. customwas evaporated under reduced pressure
  4. customThe resulting oily product was purified by column chromatography silica gel

Quellen und Nachweise

ORD-Eintrag
ord-822bce15d72446bc9e3832e14ff70787
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05021412

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