HCID 9989787, Verbindung → HCID 14999116, Verbindung

HRID 1493241Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1493241
[SH:1][CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[C:3]([OH:5])=O.[CH:15](=[N:22][CH2:23][CH2:24][N:25]([CH3:27])[CH3:26])[C:16]1[CH:21]=[CH:20][CH:19]=[N:18][CH:17]=1>C1(C)C=CC=CC=1>[CH3:26][N:25]([CH3:27])[CH2:24][CH2:23][N:22]1[C:3](=[O:5])[CH:2]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[S:1][CH:15]1[C:16]1[CH:17]=[N:18][CH:19]=[CH:20][CH:21]=1

Komponenten

4

Edukt 2

HCID 9989787HCID 9989787, VerbindungHCID 219323062-Sulfanylundecanoic acid

Produkt 1

HCID 14999116HCID 14999116, VerbindungAusbeute 90 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

2-Mercaptoundecanoic acid (2 g, 9.16 mmol) and N-nicotinylidene-N',N'-dimethylethylenediamine (1.62 g, 9.16 mmol) were dissolved in toluene (50 ml), and subjected to azeotropic dehydration for 2 hours. The solvent was removed from the product mixture by evaporation under reduced pressure The residue was purified by column chromatography, giving 3-(2-dimethylaminoethyl)-5-(n-nonyl)-2-(3-pyridyl)thiazolidin-4-one (3.1 g, 90% yield).

Aufarbeitung

  1. customThe solvent was removed from the product mixture by evaporation under reduced pressure The residue
  2. customwas purified by column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-cd47c7e918144e479a66e90049f2b7e1
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05021435

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