1-(4-methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine → HCID 14986895, Verbindung

HRID 1493595Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1493595
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([C:15]3[CH:16]=[CH:17][C:18]([N+:21]([O-])=O)=[N:19][CH:20]=3)[CH2:11][CH2:10]2)=[CH:5][CH:4]=1>C(OCC)(=O)C.[Pt]>[NH2:21][C:18]1[CH:17]=[CH:16][C:15]([N:12]2[CH2:13][CH2:14][N:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[CH2:10][CH2:11]2)=[CH:20][N:19]=1

Komponenten

4

Edukt 1

HCID 48776161-(4-methoxyphenyl)-4-(6-nitropyridin-3-yl)piperazine

Produkt 1

HCID 14986895HCID 14986895, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23939PlatinumKatalysatorHCID 8857Ethyl AcetateLösungsmittel

Versuchsvorschrift

A suspension of the product of part (i) (0.65 g, 2.0 mmole) in ethyl acetate (30 ml) was hydrogenated over 5% platinum on carbon (25 mg) at 45 p.s.i. (310 kPa) and at 50° for 12 hours, followed by 45 hours at room temperature. The resulting mixture was filtered to remove the catalyst, concentrated under reduced pressure and the residue triturated with ether to yield the desired product, m.p. 182°-188° (0.28 g, 50%), which was used without further purification.

Aufarbeitung

  1. waitfollowed by 45 hours at room temperature
  2. filtrationThe resulting mixture was filtered
  3. customto remove the catalyst
  4. concentrationconcentrated under reduced pressure
  5. customthe residue triturated with ether

Quellen und Nachweise

ORD-Eintrag
ord-4236b47c11214086b5e1a549ff117784
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05023258

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