Methylamine → Benzenamine, N-methyl-2-nitro-4-(trifluoromethyl)-

HRID 1494333Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1494333
[CH3:1][NH2:2].F[C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[N+:14]([O-:16])=[O:15]>CN(C)C=O>[CH3:1][NH:2][C:4]1[CH:9]=[CH:8][C:7]([C:10]([F:13])([F:12])[F:11])=[CH:6][C:5]=1[N+:14]([O-:16])=[O:15]

Komponenten

4

Edukt 2

HCID 6329MethylamineHCID 677784-Fluoro-3-nitrobenzotrifluoride

Produkt 1

HCID 88405Benzenamine, N-methyl-2-nitro-4-(trifluoromethyl)-Ausbeute 86 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

A stream of methylamine was bubbled through a solution of 1.3 g (6.2 mmol) 4-fluoro-3-nitrobenzotrifluoride in 25 ml dimethylformamide at 25° C. for 5 min. Stirring was continued at 25° C. for 2 h, and then the reaction mixture was evaporated in vacuo. The residue was stirred with water, and the precipitate was filtered off to give 1.17 g (86%) 4-methylamino-3-nitrobenzotrifluoride. NMR (CDCl3): 8.4 (1H, s), 8.2 (1H, broad s), 7.6 (1H, dd), 6.9 (1H, d), 3.1 (3H, d).

Aufarbeitung

  1. customthe reaction mixture was evaporated in vacuo
  2. stirringThe residue was stirred with water
  3. filtrationthe precipitate was filtered off

Quellen und Nachweise

ORD-Eintrag
ord-9966705f7d0d41cbabbf9ac7e647fa3d
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05026704

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