2-Methylimidazole → HCID 10977186, Verbindung
Reaktionsgleichung
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([CH:11]2[CH2:13][CH2:12]2)=O)=[CH:5][CH:4]=1.[CH3:14][C:15]1[NH:16][CH:17]=[CH:18][N:19]=1>>[OH:2][C:3]1[CH:4]=[CH:5][C:6]([C:9]2[C:17]3[N:16]([C:15]([CH3:14])=[N:19][CH:18]=3)[CH2:12][CH2:13][CH:11]=2)=[CH:7][CH:8]=1Komponenten
3
Reaktionsbedingungen
- Temperatur
- 225 °C
Versuchsvorschrift
25 g (0.14 mol) of cyclopropyl 4-methoxyphenyl ketone is combined with 50 g (0.61 mol) of 2-methylimidazole and heated to 225° C. under nitrogen for 16 hr. The reaction is extracted with sodium hydroxide solution and the extract neutralized with ammonium chloride. Recrystallization from methylene chloride/methanol (1:1) provides the title compound.
Aufarbeitung
- extractionThe reaction is extracted with sodium hydroxide solution
- customRecrystallization from methylene chloride/methanol (1:1)