3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde → HCID 86603322, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[N:7]=[C:6]([C:8]2[CH:9]=[C:10]([CH:13]=[CH:14][CH:15]=2)[CH:11]=O)[CH:5]=[CH:4][N:3]=1.[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][NH:26][CH:25]([C:29]#[N:30])[CH2:24]1)=[O:22])([CH3:19])([CH3:18])[CH3:17]>>[C:16]([O:20][C:21]([N:23]1[CH2:28][CH2:27][N:26]([CH2:11][C:10]2[CH:13]=[CH:14][CH:15]=[C:8]([C:6]3[CH:5]=[CH:4][N:3]=[C:2]([Cl:1])[N:7]=3)[CH:9]=2)[CH:25]([C:29]#[N:30])[CH2:24]1)=[O:22])([CH3:19])([CH3:17])[CH3:18]Komponenten
3
Versuchsvorschrift
Intermediate 1 was coupled with 3-cyano-piperazine-1-carboxylic acid tert-butyl ester (generated according to literature procedure (ref 3)) following procedure B. LC-MS showed the product had the expected M+H+ of 414.
Quellen und Nachweise
- ORD-Eintrag
- ord-599ec968feb540a88596b2b5a9e6e559
- Quelldatensatz
- uspto-grants-2010_06
- Patentnummer