2,3-Butanediol → 2-Methoxy-4,5-dimethyl-1,3,2-dioxaphospholane

HRID 1494562Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1494562
[P:1](OC)(OC)[O:2][CH3:3].[CH3:8][CH:9]([OH:13])[CH:10]([OH:12])[CH3:11]>CO>[CH3:3][O:2][P:1]1[O:13][CH:9]([CH3:8])[CH:10]([CH3:11])[O:12]1

Komponenten

4

Edukt 2

HCID 2622,3-ButanediolHCID 8472Trimethyl phosphite

Produkt 1

HCID 2717332-Methoxy-4,5-dimethyl-1,3,2-dioxaphospholane

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

A mixture of 300 g of trimethyl phosphite and 200 ml of 2,3-butanediol was heated to 100° C. and the methanol formed was distilled off to obtain 170 g of 2-methoxy-4,5-dimethyl-1,3,2-dioxaphospholane with a boiling point of 66° C. at 20 mm Hg, 37 g of the said product were added over two hours to 62.5 g of tert.-butyl bromoacetate heated to 115° C. under reduced pressure of 140 mm Hg and the volatile products were removed under reduced pressure to obtain 59 g of 2-tert.-butoxycarbonylmethyl-4,5-dimethyl-2-oxo-1,3,2-dioxaphospholane which slowly crystallized.

Aufarbeitung

  1. distillationwas distilled off

Quellen und Nachweise

ORD-Eintrag
ord-75ef9a80f5964f159923322f83e91e32
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05026862

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