2-(2-(Butylthio)2-methylpropylamino]-1-(2-mercapto-2-methylpropylamino)benzene → 2-Propanethiol, 1-anilino-2-methyl-

HRID 1494707

Reaktionsgleichung

Reaktionsgleichung von HRID 1494707
C([S:5][C:6]([CH3:22])([CH3:21])[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1NCC(S)(C)C)CCC>[Tc]([O-])(=O)(=O)=O.[Na+]>[SH:5][C:6]([CH3:22])([CH3:21])[CH2:7][NH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

Komponenten

3

Edukt 1

HCID 100268592-(2-(Butylthio)2-methylpropylamino]-1-(2-mercapto-2-methylpropylamino)benzene

Produkt 1

HCID 1431632-Propanethiol, 1-anilino-2-methyl-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 74086836Sodium pertechnetateKatalysator

Versuchsvorschrift

2-(2-(Butylthio)2-methylpropylamino]-1-(2-mercapto-2-methylpropylamino)benzene was reacted with Tc-99m sodium pertechnetate by the method of Example 7 to produce Tc-99m complex of 2-(2-butylthio)2-methylpropylamino)-1-(2-mercapto-2-methylpropylamino)benzene. The complex was purified by filtration through Millex GS and Jelco 5 micron filters. HPLC (90% ethanol/H 2 O, 1.5 ml/min, C18 5 micron Radial Pak) Rt 4.4 min (99%). TLC (50% diethyl ether/chloroform) Rf 0.89, radiochemical purity 92%. Electrophoresis (0.05 M NaH2PO4, buffer pH 4.5 constant 300 volts, 30 min) neutral.

Quellen und Nachweise

ORD-Eintrag
ord-30d7736693e04af7adb57249130b6cf8
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05026913

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