Hydrochloric Acid → 7-(5-Aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt

HRID 1494822Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1494822
C([O:3][C:4]([C:6]1[C:15](=[O:16])[C:14]2[C:9](=[N:10][C:11]([N:18]3[CH2:26][C:25]4[C:20](=[CH:21][CH:22]=[C:23]([CH2:27][NH:28]C(=O)C)[CH:24]=4)[CH2:19]3)=[C:12]([F:17])[CH:13]=2)[N:8]([CH:32]2[CH2:34][CH2:33]2)[CH:7]=1)=[O:5])C.[ClH:35]>C(O)C>[ClH:35].[NH2:28][CH2:27][C:23]1[CH:24]=[C:25]2[C:20](=[CH:21][CH:22]=1)[CH2:19][N:18]([C:11]1[N:10]=[C:9]3[C:14]([C:15](=[O:16])[C:6]([C:4]([OH:5])=[O:3])=[CH:7][N:8]3[CH:32]3[CH2:34][CH2:33]3)=[CH:13][C:12]=1[F:17])[CH2:26]2

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 572711897-(5-Acetamidomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester

Produkt 1

HCID 679223597-(5-Aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

80 mg of 7-(5-acetamidomethyl-2-isoindolinyl)-1- cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester was dissolved in a mixture of 10 ml of 10% hydrochloric acid and 10 ml of ethanol. The mixture was heated under reflux for 24 hours. The precipitates deposited were collected by filtration and washed with water and ethanol in this order to obtain 68 mg of 7-(5-aminomethyl-2-isoindolinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid hydrochloride salt.

Aufarbeitung

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 24 hours
  3. filtrationThe precipitates deposited were collected by filtration
  4. washwashed with water and ethanol in this order

Quellen und Nachweise

ORD-Eintrag
ord-2ec7002a7a8d43619d56c391fd13a0db
Quelldatensatz
uspto-grants-1991_06
Patentnummer
US05026856

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