Methyl iodide → 7-Bromo-3-methyl-3,4-dihydroquinazolin-4-one

HRID 1496853Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1496853
[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.[CH3:13]I>CN(C=O)C>[Br:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[N:7]([CH3:13])[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodide2×HCID 1355556127-Bromo-3,4-dihydroquinazolin-4-one

Produkt 1

HCID 585745147-Bromo-3-methyl-3,4-dihydroquinazolin-4-one

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Reaktionsbedingungen

Temperatur
25 °C

Versuchsvorschrift

400 mg 7-Bromoquinazolin-4(3H)-one was dissolved in DMF and 720 mg of CsCO3 and 130 μL of methyliodide were added and the mixture stirred for 3 h at 25° C. Additional 50 μL methyliodide were added and stirred overnight at 25° C. The mixture was filtered off and the mother liquor diluted with DCM and extracted with water. The solvent was removed to yield 490 mg of 7-bromo-3-methylquinazolin-4(3H)-one as solid.

Aufarbeitung

  1. stirringstirred overnight at 25° C
  2. filtrationThe mixture was filtered off
  3. additionthe mother liquor diluted with DCM
  4. extractionextracted with water
  5. customThe solvent was removed

Quellen und Nachweise

ORD-Eintrag
ord-168871d7a6094b93b910d797bb03ca6c
Quelldatensatz
uspto-grants-2015_12
Patentnummer
US09199937B2

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