Ethyl 3-chloro-3-oxopropionate → N-[4-Chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenyl]-malonamic acid ethyl ester
Reaktionsgleichung
[Cl:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([NH2:9])=[C:4]([C:10]#[C:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[Cl:18])[CH:3]=1.[CH2:19]([O:21][C:22](=[O:27])[CH2:23][C:24](Cl)=[O:25])[CH3:20]>>[CH2:19]([O:21][C:22](=[O:27])[CH2:23][C:24]([NH:9][C:5]1[C:6]([F:8])=[CH:7][C:2]([Cl:1])=[CH:3][C:4]=1[C:10]#[C:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=1[Cl:18])=[O:25])[CH3:20]Komponenten
3
Versuchsvorschrift
The title compound was prepared in analogy to example 29 step A from 4-chloro-2-(2-chloro-phenylethynyl)-6-fluoro-phenylamine (570 mg, 2.03 mmol) and chlorocarbonyl-acetic acid ethyl ester (460 mg, 3.05 mmol). White solid (440 mg, 55%) MS (ESI): 394 (M+H)+.
Quellen und Nachweise
- ORD-Eintrag
- ord-20ff7d2bb77c474b85f54dec96ab7585
- Quelldatensatz
- uspto-grants-2015_12