2-Bromoethyl methyl ether → (rac)-(3aSR,6aRS)-3-(2-Methoxy-ethyl)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl ester
Reaktionsgleichung
[C:1]([O:5][C:6]([N:8]1[CH:12]2[CH2:13][CH2:14][CH2:15][CH:11]2[NH:10][C:9]1=[O:16])=[O:7])([CH3:4])([CH3:3])[CH3:2].Br[CH2:18][CH2:19][O:20][CH3:21]>>[C:1]([O:5][C:6]([N:8]1[CH:12]2[CH2:13][CH2:14][CH2:15][CH:11]2[N:10]([CH2:18][CH2:19][O:20][CH3:21])[C:9]1=[O:16])=[O:7])([CH3:4])([CH3:2])[CH3:3]Komponenten
3
Versuchsvorschrift
The title compound was prepared in accordance with the general method of example 1, step 2 starting from (rac)-(3aSR,6aRS)-2-oxo-hexahydro-cyclopentaimidazole-1-carboxylic acid tert-butyl ester (Example 1, step 1) and using 1-bromo-2-methoxyethane instead of iodoethane to yield the desired product as a light yellow oil which was directly used in the next step without further characterisation.
Quellen und Nachweise
- ORD-Eintrag
- ord-c9776199a6e540128d96745b0853ba97
- Quelldatensatz
- uspto-grants-2015_12
- Patentnummer
- US09199971B2
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